Researchers make blood vessels from people with diabetes and discover how they are damaged

In a groundbreaking discovery, a team of researchers from Queen’s University Belfast has successfully grown a mini version of human blood vessels from people with diabetes, in the lab.
This breakthrough advances research of the disease by providing a new way for scientists to study how diabetes impacts blood vessels, potentially leading to the development of new treatments.

The study has been published  in the journal Stem Cells.

The research team, led by Professor Andriana Margariti from the Wellcome-Wolfson Institute for Experimental Medicine (WWIEM) at Queen’s University Belfast, also discovered how blood vessels in people with diabetes become damaged.

Diabetes can damage blood vessels due to high blood sugar levels, leading to a buildup of fats, cholesterol and other substances in and on the artery walls, which significantly increases the risk of heart attacks and strokes. This damage impairs blood flow and nutrient delivery, contributing to severe cardiovascular diseases.

The team identified a special small number of vascular cells present more in the blood vessels of people with diabetes that contribute to this damage, which can lead to severe complications such as heart disease and blindness.

By reducing diabetic complications such as cardiovascular disease and the risk of amputations, individuals with diabetes will experience significant health benefits and an improved quality of life in the near future.

This research breakthrough is expected to enhance our understanding of diabetes and drive the development of potential new therapies soon. These advancements are hoped to have a profound impact on the quality of life for people with diabetes in Northern Ireland, the UK, and globally.

Professor Andriana Margariti, leading researcher from the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast and the senior and corresponding author on the research, explains: “Our research is of paramount importance as it sheds new light on how diabetes damages blood vessels, leading to serious health issues like cardiovascular disease. This opens new possibilities for developing targeted therapies that can significantly improve the lives of people with diabetes.

“This discovery is revolutionary, as it not only enhances our understanding of diabetes, but also has the potential to significantly reduce the need for animal testing in research as these human models can serve as effective replacements.”

Fearghal McKinney, Head of British Heart Foundation Northern Ireland, said: “More than 110,000 adults in Northern Ireland have been diagnosed with diabetes and, across the UK, one third of adults with diabetes will die from a heart or circulatory disease.

“This research, from Professor Andriana Margariti and her team, gives us a glimpse inside blood vessels to understand how damage occurs in diabetes. We look forward to seeing how this technique is used to unlock new treatments that can reduce the impact of heart and circulatory diseases for people living with diabetes and save more families from heartbreak.”

The research was funded by the Medical Research Council (MRC), the British Heart Foundation, and the Northern Ireland Department for the Economy.

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